Pharmacology: Pharmacokinetics: Atorvastatin is rapidly absorbed after oral administration, maximum plasma levels occur within 1 to 2 hours. Although food reduces the rate and extent of absorption, LDL-C reduction is similar whether Atorvastatin is given with or without food. Atorvastatin is approximately 98% bound to plasma proteins. Atorvastatin is extensively metabolized and eliminated primarily in bile. The mean plasma elimination half life of Atorvastatin in humans is approximately 14 hours, but the half life of inhibitory activity for HMG-CoA reductase is 20-30 hours.
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