IV over 5 min or IV infusion over 20-30 min. Prophylaxis of acid aspiration 40 mg completed 1 hr before surgery. Benign gastric ulcer, duodenal ulcer & gastroesophageal reflux 40 mg once daily until PO. Possible severe peptic ulcer bleeding (unlicensed indication) Initially 80 mg by IV infusion, then 8 mg/hr by continuous IV infusion for 72 hr. Patient unsuited to receive oral therapy 40 mg of the base over a period of 20-30 min on a short-term basis by IV infusion. May also be given by slow IV inj. Zollinger-Ellison syndrome Given higher IV doses. Childn 1 mth-12 yr 500 mcg/kg (max of 20 mg) once daily. May be increased to 2 mg/kg (max of 40 mg) once daily if needed.
May affect azole antifungal agents (eg, itraconazole, ketoconazole), benzodiazepines, cilostazol, clarithromycin, digoxin, phenytoin, salicylates, sulfonylureas & warfarin; cyclosporine, disulfiram, azole antifungal agents, hydantoins. May interfere absorption of drugs where gastric pH is an important determinant of bioavailability (eg, ketoconazole, ampicillin, Fe salts, digoxin, cyanocobalamin). Drugs that affect PPIs include clarithromycin & sucralfate.
A02BC01 - omeprazole ; Belongs to the class of proton pump inhibitors. Used in the treatment of peptic ulcer and gastro-oesophageal reflux disease (GERD).
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