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Hypersensitivity reactions range from mild to life-threatening. Administer drug with caution to penicillin-sensitive patients because of possible cross-reactivity.
Use in patients with renal insufficiency: Use with caution in patients with renal insufficiency. Reduce dose when creatinine clearance is less than 20 mL/min.
Gastrointestinal: Use with caution in patients with history of colitis.
Local Reactions: Local irritation may occur on the infusion sites. Regularly monitor infusion sites and change location when it is needed.
Use in the Elderly: Because elderly are more likely to have decreased renal function, care should be taken in dose selection and consider monitoring in renal function.
Use in Pregnancy & Lactation: Cefotaxime-Sulbactam is included in Pregnancy Category B. Both drugs are excreted in breast milk; caution should be exercised in nursing mothers.
