Prophylaxis of venous thrombosis in surgical patient Patient w/ moderate risk of thromboembolism 20 or 40 mg SC once daily. Give 1st inj 2 hr before surgical procedure.
Patient w/ high risk of thromboembolism 40 mg SC once daily, initiated 12 hr pre-op or 30 mg bid, initiated 12-24 hr after surgery. Ave duration: 7-10 days. May continue therapy as long as there is venous thrombo-embolism risk & until patient is ambulatory eg, 40 mg once daily for 3 wk in orthopedic surgery.
Prophylaxis of venous thrombo-embolism in medical patient 40 mg SC once daily for a min of 6 days & continued until return to full ambulation. Max: 14 days.
DVT w/ or w/o pulmonary embolism 1.5 mg/kg SC once daily or 1 mg/kg SC bid.
Patient w/ complicated thrombo-embolic disorders 1 mg/kg SC bid. Ave duration: 10 days. Initiate oral anticoagulant therapy when appropriate & continue treatment until therapeutic anticoagulant effect has been achieved (INR 2-3).
Prevention of extracorporeal thrombus during hemodialysis 1 mg/kg introduced into the arterial line of the circuit prior to hemodialysis, sufficient for a 4-hr session. Additional dose of 0.5-1 mg/kg may be given if fibrin rings are found eg, after longer sessions.
Patient w/ high risk of hemorrhage Reduced dose to 0.5 mg/kg for double vascular access or 0.75 mg/kg for single vascular access.
Unstable angina & non-Q-wave MI 1 mg/kg SC every 12 hr w/ aspirin PO (100-325 mg once daily) for min of 2 days & continued until clinical stabilization (usual duration: 2-8 days).
Acute ST-segment elevation MI 30 mg single IV bolus + 1 mg/kg SC followed by 1 mg/kg SC every 12 hr. Max: 100 mg for 1st 2 doses only, followed by 1 mg/kg SC for the remaining doses. Give 15 min before & 30 min after start of fibrinolytic therapy when administered in conjunction w/ a fibrin/non-fibrin specific thrombolytic. Recommended duration: 8 days or until hospital discharge, whichever comes first.
Elderly ≥75 yr Initially 0.75 mg/kg SC every 12 hr (max: 75 mg for 1st 2 doses only, followed by 0.75 mg/kg SC for the remaining doses).
Patient managed w/ percutaneous coronary intervention Last enoxaparin Na SC administration given <8 hr before balloon inflation: no additional dosing needed. Last SC administration given >8 hr before balloon inflation: Administer 0.3 mg/kg IV bolus of enoxaparin Na.
Severe renal impairment 1 mg/kg SC once daily.
Acute STEMI in patient ≥75 yr 1 mg/kg SC once daily w/o initial bolus. Max: 100 mg for 1st SC dose.
Acute STEMI in patient <75 yr 30 mg single IV bolus + 1 mg/kg SC, followed by 1 mg/kg SC once daily. Max: 100 mg for 1st SC dose.
Prophylaxis 20 mg SC once daily.