Clopixene Overdosage

The most commonly reported signs and symptoms associated with Clozapine overdosage are altered states of consciousness, including drowsiness, delirium and coma; tachycardia; cardiac arrhythmias have also been reported with Clozapine generally at doses above 2500 mg. There have also been of patients recovering from overdoses well in excess of 4 g.
Treatment: Establish and maintain an airway; ensure adequate oxygenation and ventilation. Activated charcoal, which may be used with sorbitol, may be as or more effective than emesis or lavage, and should be considered in treating overdosage. Cardiac and vital signs monitoring is recommended along with general symptomatic and supportive measures. Additional surveillance should be continued for several days because of the risk of delayed effects. Avoid epinephrine and derivatives when treating hypotension, and quinidine and procainamide when treating cardiac arrhythmia. There are no specific antidotes for Clozapine. Forced diuresis, dialysis, hemoperfusion and exchange transfusion are unlikely to be of benefit.