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Hypertension: 150 mg once daily, increased to 300 mg once daily, if necessary. Elderly >75 Years, Patients with Intravascular Volume Depletion and Those Receiving Hemodialysis: A lower initial dose of 75 mg once daily may be considered. Children 6-12 Years: 75 mg once daily, increased to 150 mg once daily, if necessary.
Renal Disease in Hypertensive Type II Diabetes: Initial Dose: 150 mg once daily, increased to 300 mg once daily for maintenance. Hydrochlorothiazide is normally effective at 12.5 mg daily dose but may be increased to 25-50 mg, if necessary. Irbesartan is normally given in the morning so that sleep is not interrupted by diuresis.
