Pharmacology: Depofemme administered parenterally as an IM injection provides long-acting progestational effect by inhibiting gonadotropin production, which in turn prevents follicular maturation and ovulation. This will cause a long-term unovulation in women of reproductive age. Depofemme causes progestational changes in the cervical mucus, in which it becomes more viscous, inhibiting sperm penetration into uterus. This steroid also produces morphological changes of endometrium, thereby increasing the difficulty of nidation.
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