Dopezil

Dopezil

donepezil

Manufacturer:

UNILAB, Inc

Distributor:

UNILAB, Inc
Concise Prescribing Info
Contents
Donepezil HCl
Indications/Uses
Mild, moderate & severe Alzheimer's disease; vascular dementia (dementia associated w/ cerebrovascular disease); dementia w/ Lewy bodies (DLB).
Dosage/Direction for Use
Adult & elderly Initially 5 mg once daily in the evening for at least 1 mth. May be increased up to a max of 10 mg once daily.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity to donepezil HCl or piperidine derivatives.
Special Precautions
Patients w/ & w/o known underlying cardiac conduction abnormalities; history of asthma or obstructive pulmonary disease. Monitor closely for symptoms of active or occult GI bleeding, particularly those at increased risk for developing ulcers. Neuroleptic malignant syndrome. Rhabdomyolysis. Caution in patients w/ risk of aggression. Succinylcholine-type muscle relaxation during anesth. Bladder outflow obstruction. May impair ability to drive or operate machinery. Renal & hepatic impairment. Pregnancy & lactation. Elderly.
Adverse Reactions
Asthenia, fungal infection, flu syndrome, malaise, sepsis, face edema, hernia, fever, back pain, pain, headache, infection, accident; CV, nervous system, GI, hematologic, musculoskeletal, metabolic/nutritional, resp, hepatic, skin & appendages, urogenital/reproductive & special senses effects.
Drug Interactions
Inhibited metabolism w/ inhibitors of CYP3A4 (eg, ketoconazole, itraconazole, erythromycin) & CYP2D6 (eg, quinidine, fluoxetine). Increased rate of elimination w/ CYP2D6 & CYP3A4 inducers (eg, phenytoin, carbamazepine, dexamethasone, rifampicin, & phenobarb). Potential to interfere activity w/ anticholinergics. Synergistic effect w/ cholinomimetics & other cholinesterase inhibitors.
MIMS Class
Neurodegenerative Disease Drugs
ATC Classification
N06DA02 - donepezil ; Belongs to the class of anticholinesterases. Used in the management of dementia.
Presentation/Packing
Form
Dopezil FC tab 10 mg
Packing/Price
30's (P2,655.99/box, P88.53/film-coated tab)
Form
Dopezil FC tab 5 mg
Packing/Price
30's (P66.9/film-coated tab, P2,006.98/box)
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