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Pharmacology: Pharmacodynamics: Mechanism of Action: Isoxsuprine is a vasodilator which also stimulates beta-adrenergic receptors. It causes direct relaxation of vascular and uterine smooth muscle and its vasodilating action is greater on the arteries supplying skeletal muscle than on those supplying skin. Isoxsuprine also produces positive inotropic and chronotropic effects.
Pharmacokinetics: Isoxsuprine hydrochloride is well absorbed from the gastrointestinal tract. The peak plasma concentration occurs about 1 hour after administration by mouth. A plasma half-life of 1.5 hours has been reported. Isoxsuprine is excreted in the urine mainly as conjugates.
