Increased effect of anticoagulant. May increase phenytoin levels. Enhanced metabolism w/ carbamazepine & phenytoin. Increase metabolism & excretion w/ rifampicin & barbiturates. Cardiac glycosides (dosage adjustment may be necessary). Enhanced effects of sympathomimetic agents. Accelerated TCA response. Decreased absorption w/ cholestyramine; Ca- , Al-, Mg-, Fe supplements, Al hydroxide, polystyrene sulfonates, sucralfate, lanthanum, bile acid sequestrants (eg, colestipol), anion/cation exchange resins (eg, kayexalate, sevelamer), Ca carbonate & ferrous sulphate; PPIs. Decreased intestinal absorption w/ soy-containing compd & high fibre diets. OCs; other drugs, including oestrogen, tamoxifene, clofibrate, methadone & 5-flurouracil may increase serum conc of thyroxine-binding globulin. HMG-CoA reductase inhibitors (statins) may increase thyroid hormone requirements. Drugs that may decrease serum conc of thyroxine-binding globulin, including androgens & anabolic steroids. Tyrosine kinase inhibitors (eg, imatinib & sunitinib) was associated w/ increased Levothyroxine Na dosage requirements in hypothyroid patients. Propranolol, amiodarone, lithium, iodide, oral contrast agents, propylthiouracil, glucocorticoids lower T3 level & therefore also the therapeutic effect. Sertraline can reduce serum levels of thyroxine. Levothyroxine can increase the need for insulin or oral antidiabetics in patients w/ diabetes. Potential interaction between ritonavir containing products & levothyroxine.