Epimate-50 Dosage/Direction for Use

Epilepsy: Adult: 25 mg once daily by mouth for one week increased thereafter by increments of 25 to 50 mg at intervals of one to two weeks. Daily dose of more than 25 mg should be taken in 2 divided doses.
Adjunctive Therapy: The usual dose for adjunctive therapy is 200 to 400 mg, although some patients may require up to 800 mg daily.
Monotherapy: Usual ranges range from 100 mg to a maximum of 400 mg daily.
Children: Adjunctive Therapy: Children aged 2 to 16 years is 25 mg nightly for the first week, increased at intervals of one to two weeks by increments of 1 to 3 mg/kg/day. The recommended dose thereafter is about 5 to 9 mg/kg/day given in 2 divided doses, though up to 30 mg/kg/day may be given.
Monotherapy: Children aged 6 years and over may be started on 0.5 to 1 mg /kg at night for the first week, increased at intervals of one to two weeks by increments of 0.5 to 1 mg/kg/day. The usual dose is 3 to 6 mg/kg/day in 2 divided doses, although higher doses have been tolerated.
Migraine: Adult: 25 mg per day administered nightly for the first week and increased thereafter by increments of 25 mg. Dosage of more than 25 mg should be taken in 2 divided doses. Usual dose is 100 mg. Dose and titration should be guided by clinical outcome.
Administration in Patients with Renal Impairment: In renally impaired patients (creatinine clearance less than 70 mL/min/1.73 m²), one half of the adult dose is recommended.
Patients Undergoing Hemodialysis: Topiramate is cleared by hemodialysis, a prolonged period of dialysis may cause topiramate concentration to fall below that required to maintain an anti-seizure effect. Thus, in patients undergoing hemodialysis a supplemental dose equal to about one-half of the daily dose should be given in divided doses (at the start and finish of the procedure).
Topiramate tablets may be taken with or without food. Swallow whole, do not chew or crush.