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Pharmacology: Pharmacodynamics: Ibuprofen is a synthetic analgesic and anti-inflammatory agent with a marked antipyretic effect.
Chemically, it represents the progenitor of phenylpropionic derivatives w/ anti-inflammatory activity. Its analgesic activity is not narcotic. Ibuprofen is a powerful prostaglandin synthesis inhibitor and exerts its activity by inhibiting its synthesis peripherally.
Pharmacokinetics: Ibuprofen arginine, due to the presence of a basic amino acid eg, arginine, allows ibuprofen solubilization and assures an excellent and prompt absorption of the active ingredient after oral administration.
Studies on man show that ibuprofen arginine, a new ibuprofen preparation enables a prompter drug absorption with respect to other traditional pharmaceutical forms (the peak concentration appears earlier) and with a serum bioavailability higher in the 1st hour following drug administration.
The peak plasma concentration is reached approximately within 15-30 min and plasma levels are attained within 5-10 min after oral administration. This feature is particularly advantageous in clinical conditions (eg, intense pain) where a prompt analgesic effect is required.
Ibuprofen arginine administration did not result in the accumulation of either the drug or its metabolites since excretion is practically complete after 24 hrs.
Toxicology: Preclinical Safety Data: Toxicological tests performed in various animal species by different routes of administration demonstrated that ibuprofen is well-tolerated and did not show teratogenic effects. It must however be pointed out that administration of NSAIDs to pregnant rats may induce a restriction of Botallo's duct.
