Fucid

Fusidic acid.

Each gram contains: Fusidic Acid 20 mg, Cream base q.s.

Pharmacology: Pharmacokinetics: Fusidate has strong surface activity and exhibit unusual ability to penetrate intact skin. The degree of penetration depends on factors such as duration of exposure to fusidic acid and condition of skin. It is excreted in the bile, almost entirely as metabolites, some of which have weak antimicrobial activity.
Microbiology: Antimicrobial Action: Fusidic acid is a steroidal antibacterial with a bacteriostatic or bactericidal activity, mainly against Gram-positive bacteria.
Mechanism of action: Fusidic acid inhibits bacterial protein synthesis although, in contrast to drugs such as the macrolides or tetracyclines, it does not bind to the bacterial ribosome, but inhibits a factor necessary for translocation of peptide subunits and elongation of the peptide chain. It is capable of inhibiting protein synthesis in mammalian cells but exerts a selective action against susceptible infecting organisms because of poor penetration into the host cell.
Spectrum of activity: Fusidic acid is very active against staphylococci, notably, Staph. aureus and Staph. epidermidis (including methicillin-resistant strains). Nocardia asteroides and many clostridia strains are also highly susceptible. The streptococci and enterococci are less susceptible. Most Gram-negative bacteria are intrinsically resistant but fusidic acid is active against Neisseria spp. and Bacteroides fragilis. It has some activity against strains of Mycobacterium tuberculosis and is highly active against M. leprae. Fungi are resistant, but fusidic acid has some activity against a range of protozoa including Giardia lamblia and Plasmodium falciparum. High concentrations of fusidate are reported to inhibit viral growth in vitro, including that of HIV, although it is unclear whether this represents a surfactant effect, a general cytotoxic effect, or a genuine antiviral action.
Activity with other antimicrobials: No synergy has been demonstrated in vitro in most studies between fusidic acid and rifampicin or vancomycin, and antagonism of the effects of ciprofloxacin has been reported. Interactions with the penicillins are complex, with either antagonism of the effect of one or both drugs, or no interaction. However, use of an antistaphylococcal penicillin with fusidic acid may prevent the emergence of fusidic acid-resistant staphylococcal mutants, and such combinations may be clinically effective.
Resistance: Resistant strains of staphylococci are readily selected in vivo, and occasionally during therapy, but the number of clinical isolates that are initially resistant remains relatively low at about 1 to 2% overall, despite widespread topical use. Resistance may be chromosomally mediated, representing altered protein synthesis, or plasmid-mediated, which appears to be due to reduced penetration of active drug into the cell.

Fusidic acid and its salts are antibacterials used mainly in the treatment of staphylococcal infections, often with other drugs. They have been used in the treatment of abscess, including brain abscess, in bone and joint infections, in staphylococcal infections in patients with cystic fibrosis, in the treatment of staphylococcal endocarditis, and topically in eye infections and infections of the skin.

Apply to the affected area twice to thrice daily for seven (7) days or as prescribed by the physician.

Fusidic acid competes with bilirubin for binding to albumin in vitro and caution has been advised if it is given to premature, jaundiced, acidotic, or seriously-ill neonates because of the risk of kernicterus.
FOR EXTERNAL USE ONLY.

Hypersensitivity reactions in the form of rashes and irritation may occur with topical fusidate.

Store at temperatures not exceeding 25°C.

Topical Antibiotics

D06AX01 - fusidic acid ; Belongs to the class of other topical antibiotics used in the treatment of dermatological diseases.

Rx