Funxion Overdosage

In overdoses up to 15 g, no unexpected adverse effects were reported. In postmarketing experience, fatal outcomes in cases in which pregabalin has been taken in combination with other drugs have been reported with a pregabalin overdose as low as 800 mg per day. In none of these cases has pregabalin been established as the cause of death or in pregabalin monotherapy.
The most commonly reported adverse events observed when pregabalin was taken in overdose (dose range: 800 mg/day to 11,500 mg as a single dose) include affective disorder, somnolence, confusional state, depression, agitation, and restlessness.
There is no specific antidote for pregabalin. Treatment of pregabalin overdose should be symptomatic and supportive including monitoring of vital signs and observation of the clinical status of the patient. Consider administration of activated charcoal in the event of a potentially toxic ingestion. Activated charcoal is most effective when administered within one hour of ingestion. In patients who are not fully conscious or have impaired gag reflex, consideration should be given to administering activated charcoal via nasogastric tube once the airway is protected.
Hemodialysis may be useful in patients with severe toxicity or those with significant renal impairment. Standard hemodialysis procedures result in significant clearance of pregabalin (approximately 50% in four hours). Emesis is not recommended because of the potential for CNS depression and seizures.