Furosan Dosage/Direction for Use

Alternatively, it may be administered intramuscularly or intravenously as the sodium salt; doses are expressed in terms of furosemide base. The manufacturers recommend that whether by direct intravenous injection or by infusion the rate of intravenous administration should not exceed 4 mg per minute although some authorities advise that a single dose of up to 80 mg may be given more rapidly. In treatment of oedema, when oral therapy cannot be given, 20 mg to 50 mg of Furosemide may be administered by intramuscular or slow intravenous injection; if necessary further doses may be given, increasing by 20 mg increments and not given more often than every 2 hours. If doses greater than 50 mg are required, they should be given by slow intravenous infusion. For pulmonary oedema, if an initial slow intravenous injection of 40 mg doses not produce a satisfactory response within one hour, the dose may be increased to 80 mg given slowly intravenously.
For children, doses by injection are 0.5 to 1.5 mg per kg daily up to a maximum of 20 mg daily.
High dose therapy, in the management of oliguria in acute or chronic renal failure where the glomerular filtration rate is less than 20 mL per minute Furosemide 250 mg diluted to 250 mL in a suitable diluents is infused over one hour. If urine output is insufficient within the next hour, this dose may be followed by 500 mg added to an appropriate infusion fluid, the total volume of which must be governed by the patient's state of hydration and infused over approximately 2 hours. If a satisfactory urine output has still not been achieved within one hour of the end of the second infusion then a third dose of 1 g may be infused over approximately 4 hours. The rate of infusion should never exceed 4 mg per minute. In oliguric patients with significant fluid overload, the injection may be given without dilution directly into the vein, using a constant rate infusion pump with a micrometer screw-gauge adjustment; the rate of administration should still never exceed 4 mg per minute. Patients who do not respond to a dose of 1 g probably required dialysis.
During treatment with these high-doses forms of Furosemide therapy, careful laboratory control is essential, Fluid balance and electrolytes should be carefully controlled and, in particular, in patient with shock, measures should be taken to correct the blood pressure and circulating blood volume, before commencing this type of treatment.
Or as prescribed by a physician.