EpilepsyAdult & childn >12 yr 900-3600 mg/day. Start w/ 300 mg tid or by dose titration: Day 1: 300 mg once daily; Day 2: 300 mg bid; Day 3: 300 mg tid. Thereafter, increase dose in increments of 300 mg/day for 2-3 days up to max dose of 3600 mg/day. Childn ≥6 yr Starting dose: 10-15 mg/kg/day. Effective dose: 25-35 mg/kg/day up to 50 mg/kg/day in 3 divided doses. Max time interval between doses is not >12 hr. Neuropathic pain Titrate dose similar to treatment of epilepsy or start w/ 900 mg/day in 3 divided doses up to a max of 3600 mg/day. Patient w/ impaired renal function CrCl ≥80 mL/min 900-3600 mg/day; 50-79 mL/min 600-1800 mg/day; 30-49 mL/min 300-900 mg/day; 15-29 mL/min 150-600 mg/day (150 mg to be administered as 300 mg every other day); <15 mL/min 150-300 mg/day (150 mg to be administered as 300 mg every other day). Undergoing hemodialysis 300-400 mg then 200-300 mg following each 4 hr of hemodialysis.
View Gabix overdosage for action to be taken in the event of an overdose.
Administration
May be taken with or without food.
Special Precautions
Discontinue treatment if patient develops acute pancreatitis. Abrupt w/drawal of anticonvulsant agent in epileptic patients may precipitate status epilepticus. Mixed seizure including absence seizure. Patients w/ compromised renal function & on hemodialysis. May impair ability to drive or operate machinery. Pregnancy & lactation. Elderly.
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