IV infusion Adult Nonsmall cell lung cancer Monotherapy: 1,000 mg/m
2 over 30 min once wkly for up to 3 wk, followed by 1 wk rest period. Combination therapy: Gemcitabine (3- or 4-wk schedule) + cisplatin 100 mg/m
2 IV on day 1. 4-wk schedule: 1,000 mg/m
2 over 30 min on days 1, 8 & 15 of each 28-day cycle; 3-wk schedule: 1,250 mg/m
2 over 30 min on days 1 & 8 of each 21-day cycle.
Pancreatic cancer 1,000 mg/m
2 over 30 min once wkly for up to 7 wk, followed by 1 wk rest period. Subsequent cycle: Once wkly for 3 consecutive wk out of 4 wk.
Breast cancer Paclitaxel 175 mg/m
2 by 3-hr on day 1 + gemcitabine 1,250 mg/m
2 over 30 min on days 1 & 8 of each 21-day cycle.
Bladder cancer 1,000 mg/m
2 over 30 min on days 1, 8 & 15 of each 28-day cycle (followed by 1 wk rest period) + cisplatin 70 mg/m
2 on day 1 or 2 of each 28-day cycle.
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