May intensify effect w/ insulin or oral hypoglycemic agents. May intensify effects of antihypertensive medication (especially w/ prazosin). Stronger drop in BP w/ nitroglycerine or nifedipine-type Ca antagonist, verapamil or diltiazem-type Ca antagonist or other anti-arrhythmic agents. Lower hypertensive reactions w/ adrenaline or other substances w/ sympathomimetic actions & cardioselective β-blockers. Stronger drop in cardiac frequency or delay in stimulus conduction in heart w/ reserpine, α-methyldopa, clonidine, guanfacine or cardiac glycosides. Decreased plasma conc w/ rifampicin. Increased plasma conc w/ cimetidine. May reduce the hypotensive effect w/ indomethacin. May reduce elimination of other medications. Intensified sedative effect w/ alcohol. Anesth, clonidine.
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