Hytaz Drug Interactions

Lithium: Volume depletion increases lithium absorption and may cause lithium toxicity, unless levels are closely monitored and dosage reduced accordingly. Conversely, sudden stopping of diuretic treatment may result in sub-therapeutic levels of circulating lithium.
Anticancer Drugs: Thiazide diuretics may potentiate the bone marrow suppression caused by cancer chemotherapy.
Aminoglycoside Antibiotics: Diuretic-induced volume depletion can potentiate aminoglycoside nephrotoxicity.
Diabetic Therapy: Thiazides can impair control of diabetes mellitus by diet and oral hypoglycemic agents.
Cardiac Glycosides: Digitalis toxicity caused by hypokalemia may be precipitated.
Corticosteroids: There is an increased risk of hypokalemia when the drugs are given concurrently.
Tubocurarine: Prolonged paralysis may occur due to hypokalemia.