Benign gastric & duodenal ulcer including NSAID-induced gastric & duodenal ulcer or gastroduodenal erosion 20 mg once daily for 4 wk in duodenal ulceration or 8 wk in gastric ulceration. May be increased to 40 mg daily in severe case.
GERD 20 mg once daily for 4 wk, followed by further 4-8 wk if not fully healed.
Patient w/ reflux oesophagitis refractory to other therapy 40 mg daily for 8 wk, can be continued at 20 mg once daily.
Acid-related dyspepsia 20 mg once daily for 2-4 wk.
Zollinger-Ellison syndrome Initially 60 mg once daily. Usual range: 20-120 mg daily (>80 mg in 2 divided doses); larger dose up to 180 mg daily in divided doses may be used.
H. pylori eradication in PUD 40 mg once daily. Triple therapy regimen: Omeprazole 20 mg bid w/ 1 of the following combinations: Amoxicillin 500 mg & metronidazole 400 mg both tid for 1 wk or clarithromycin 250 mg & metronidazole 400 mg (or tinidazole 500 mg) both bid for 1 wk or amoxicillin 1 g & clarithromycin 500 mg both bid for 1 wk.
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