Intermittent IV infusion over 30 min or deep IM injAdult 1-2 g daily as a single dose or in 2 divided doses. Severe infection Up to 4 g daily. Childn 50-75 mg/kg daily in 2 divided doses. Max total daily dose of 2 g. Meningitis Childn 100 mg/kg daily in 2 divided doses. Loading dose: 75 mg/kg. Max total daily dose of 4 g. Gonorrhea Adult 250 mg IM single dose. Surgical infection prophylaxis Adult 1 g single dose 0.5-2 hr prior to surgery.
History of penicillin allergy; patient w/ poor oral ingestion or in parenteral nutrition; gallbladder, biliary tract, liver or pancreatic disease. Superinfection may occur w/ prolonged therapy. Severe renal disorder. Pregnancy & lactation. Elderly.
Hypersensitivity; granulocytopenia, eosinophilia, thrombocytosis, leukopenia; elevation of GOT & AL-P, symptomatic precipitation of ceftriaxone Ca salt in gall bladder; nausea, vomiting, loose stools, diarrhea; headache.
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