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Concomitant administration of calcium-containing drugs may cause or aggravate elevated serum
calcium levels.
Drugs that form hardly soluble compounds with calcium (e.g. tetracyclines, quinolines such as
ciprofloxacin and norfloxacin as well as drugs containing iron, fluoride or estramustine) should not be
taken at the same time with Ketonol to avoid disturbed absorption of the active substances. An interval of at least two hours should elapse between the ingestion of Ketonol and these drugs.
The susceptibility to cardioactive glycosides, and hence the risk for arrhythmia will increase if Ketonol
produces elevated serum calcium levels.
Uraemic symptoms improve under therapy with Ketonol. Thus, in case of aluminium hydroxide administration, the dose of this drug has to be reduced if necessary. Serum phosphate levels should be monitored for a decrease.
