Adults suffering from MI (from a few days until <35 days), ischaemic stroke (from 7 days until <6 mth) or established peripheral arterial disease. In combination w/ ASA for non-ST segment elevation including patients undergoing a stent placement following percutaneous coronary intervention or for ST-segment elevation acute MI in medically treated patients eligible for thrombolytic therapy. In combination w/ ASA for the prevention of atherothrombotic & thromboembolic events including stroke in adults w/ atrial fibrillation who have at least 1 risk factor for vascular events, not suitable for treatment w/ vit K antagonists & has a low bleeding risk.
Adult & elderly 75 mg as a single dose. Patient suffering from non-ST segment elevation acute coronary syndrome (unstable angina or non-Q-wave MI) Initially 300 mg as a single loading dose then continued at 75 mg once daily. Patient suffering from ST segment elevation acute MI Initially 300 mg as a single loading dose in combination w/ ASA & w/ or w/o thrombolytics then continued at 75 mg as a single daily dose. Patient >75 yr Initiate therapy w/o a loading dose. Atrial fibrillation 75 mg as a single daily dose + ASA 75-100 mg daily.
View Khrizvix overdosage for action to be taken in the event of an overdose.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity to clopidogrel bisulfate, or to soya or peanut oil. Active pathological bleeding eg, peptic ulcer or intracranial haemorrhage. Severe hepatic impairment.
Cross-reactions among thienopyridines. Consider acquired haemophilia in cases of confirmed isolated aPTT prolongation w/ or w/o bleeding. Not recommended during the 1st 7 days of acute ischaemic stroke. Patients who are poor CYP2C19 metabolisers. Rarely, TTP. Consider blood cell count determination &/or other appropriate testing whenever clinical symptoms suggestive of bleeding arise during the course of treatment. Concomitant use w/ CYP2C8 substrates. Renal & moderate hepatic impairment. Do not use during pregnancy. Lactation. Not to be used in childn.
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