Lacipil Special Precautions

In specialised studies lacidipine has been shown not to affect the spontaneous function of the SA node or to cause prolonged conduction within the AV node. However the theoretical potential for a calcium antagonist to affect the activity of the SA and AV nodes should be noted, and therefore Lacidipine (Lacipil) should be used with caution in patients with pre-existing abnormalities in the activity of the SA and AV nodes.
As has been reported with other dihydropyridine calcium channel antagonists, Lacidipine (Lacipil) should be used with caution in patients with congenital or documented acquired QT prolongation. Lacidipine (Lacipil) should also be used with caution in patients treated concomitantly with medications known to prolong the QT interval such as, class I and III antiarrhythmics, tricyclic antidepressants, some antipsychotics, antibiotics (e.g. erythromycin) and some antihistamines (e.g. terfenadine).
As with other calcium antagonists, Lacidipine (Lacipil) should be used with caution in patients with poor cardiac reserve.
As with other dihydropyridine calcium antagonists Lacidipine (Lacipil) should be used with care in patients with unstable angina pectoris.
Lacidipine (Lacipil) should be used with caution in patients after recent myocardial infarction.
Lacidipine (Lacipil) should be used with caution in patients with impaired liver function because antihypertensive effect may be increased.
There is no evidence that Lacidipine (Lacipil) impairs glucose tolerance or alters diabetic control.
Effects on Ability to Drive and Use Machines: None reported.