100 mg/25 mg tid. May be increased by 1 tab daily or every other day. Max: 2 g/200 mg. Maintenance: Individualized dosage. At least 70-100 mg carbidopa/day. When more levodopa is required, 250 mg/25 mg should be substituted at a dosage of 1 tab tid or qid. If necessary, 250 mg/25 mg may be increased by ½-1 tab every other day to a max of 8 tab/day.
Patient receiving levodopa Discontinue levodopa at least 12 hr before therapy. Levodopa + carbidopa should be given as the 1st morning dose after a night w/o any levodopa. Dose should be approx 20% of the previous levodopa daily dose. Levodopa requirement >1,500 mg/day: 1 tab (250 mg/25 mg) tid-qid. Levodopa requirement <1,500 mg/day: 1 tab (100 mg/25 mg) tid-qid.
Patient receiving levodopa w/ another decarboxylase inhibitor combination Discontinue levodopa at least 12 hr before starting therapy. Start w/ the same amount of levodopa as w/ another levodopa + decarboxylase inhibitor.
Patient receiving other antiparkinsonian agent Dose adjustment may be necessary.
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