Lentira Dosage/Direction for Use

Partial Onset Seizures: Adults 16 years and older: Initial daily dose of 1000 mg/day given as twice-daily dosing (500 mg twice daily).
4 years to <16 years: Initial daily dose of 20 mg/kg in 2 divided doses (10 mg/kg twice daily). The daily dose should be increased every 2 weeks by increments of 20 mg/kg to the recommended daily dose of 60 mg/kg (30 mg/kg twice daily).
6 months to <4 years: Initial daily dose of 20 mg/kg in 2 divided doses (10 mg/kg twice daily). The daily dose should be increased in 2 weeks by an increment of 20 mg/kg to the recommended daily dose of 50mg/kg (25 mg/kg twice daily).
1 month to <6 months: Initial daily dose of 14 mg/kg in two divided doses (7 mg/kg twice daily).
Myoclonic Seizures in patients 12 years of age and older: Treatment should be initiated with a dose of 1000 mg/day, given as twice-daily dosing (500 mg twice daily). Dosage should be increased by 1000 mg/day every 2 weeks to the recommended daily dose of 3000 mg.
Primary generalized tonic-clonic seizures: Adult 16 years and older: Treatments should be initiated with a dose of 1000 mg/day, given as twice-daily dosing (500 mg twice daily).
Pediatric patients ages 6 to < 16 years: Treatment should be initiated with a daily dose of 20 mg/kg in 2 divided doses (10 mg/kg twice daily).