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Adult and Elderly Patients: The recommended dose of Letrozole is 2.5 mg once daily. In the adjuvant setting, treatment with Letrozole should continue for 5 years or until tumour relapse occurs, whichever comes first. Following standard adjuvant tamoxifen therapy, treatment with Letrozole should continue for 5 years or until tumour relapse occurs, whichever comes first. In patients with metastatic disease, treatment with Letrozole should continue until tumour progression is evident. Regular monitoring to observe progression during the pre-operative treatment period is recommended. No dose adjustment is required for elderly patients.
Children: Not recommended for use in children.
Patients with Hepatic and/or Renal Impairment: No dosage adjustment is required for patients with mild to moderate hepatic impairment (Child-Pugh grade A and B) or renal impairment (creatinine clearance).
