Levobest Dosage/Direction for Use

Patients receiving oral or intravenous (IV) levofloxacin should be well hydrated to prevent formation of highly concentrated urine. Crystalluria and cylindruria have been reported with quinolones.
Levofloxacin should be given or taken at the same time each day.
Levofloxacin Tablet: Levofloxacin tablet can be taken with or without food. Administer dose at least 2 hours before or 2 hours after antacids containing calcium, magnesium or aluminum, after sucralfate or metal cations such as iron, multivitamin preparations with zinc, or didanosine. Concomitant administration with these drugs may significantly decrease levofloxacin absorption.
Usual Recommended Dose: Orally, 500 mg or 750 mg once every 24 hours. The dose and duration of treatment are based on the type and severity of infection being treated (See Dosing Table) (see Tables 3 and 4).

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When only the serum creatinine value is available, the following formula may be used to estimate creatinine clearance. The serum creatinine should represent a steady of renal function: see equation and Table 5.

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