Levocet-Natrapharm Dosage/Direction for Use

Children ≥12 years: 5 mg once daily; alternatively, 2.5 mg once daily may be adequate for some patients.
Elderly: Select dosage with caution (usually starting at low end of dosage range) because of age-related decreases in hepatic, renal and/or cardiac function, and concomitant disease and drug therapy. (See Use in the elderly under Precautions.)
Renal Impairment: The dose of levocetirizine hydrochloride should be reduced in patients with renal impairment according to creatinine clearance (CrCl), although recommendations can vary between countries. The following oral doses have been suggested for adults in the United Kingdom (UK) and for adults and adolescents ≥12 years in the United States of America (USA): CrCl 50-79 mL/min: 5 mg once daily in the UK; 2.5 mg once daily in the USA.
CrCl 30-49 mL/min: 5 mg every other day in the UK; 2.5 mg every other day in the USA.
CrCl 10-29 mL/min: 5 mg once every 3 days in the UK; 2.5 mg once every 3 or 4 days in the USA.
CrCl <10 mL/min and patients undergoing dialysis: contraindicated both in the UK and USA.
Data are lacking for the use of levocetirizine in children with renal impairment. The dose should be adjusted on an individual basis, taking into account the patient's renal clearance and body weight.
Administration: Administer orally once daily in the evening without regard to meals.