Levorin

Levocetirizine dihydrochloride.

Each film-coated tablet contains: Levocetirizine dihydrochloride 5 mg.

For the symptomatic relief of allergic conditions including rhinitis and chronic urticaria.

The usual oral dose of Levocetirizine is 5 mg once daily.
For children the following dosages may be given: 6 to 11 years old: 2.5 mg once daily.
12 years and above: 5 mg once daily.
For patients with renal impairment the following dosages are applicable: CC 50 to 79 mL/min: 2.5 mg once daily.
CC 30 to 49 mL/min: 2.5 mg every other day.
CC 10 to 29 mL/min: 2.5 mg once every 3 or 4 days.

Drowsiness, although rare, may occur and may affect the performance of skilled tasks. Occasional reports of convulsions in patients taking antihistamines suggest a need for caution in patients with epilepsy. Many antihistamines are excreted in the urine in the form of active metabolites so that dosage reduction may be necessary in renal impairment. Caution is also needed in hepatic impairment. Antihistamines should not be given to neonates because the latter is more susceptible to antimuscarinic effects. It also has been recommended that antihistamines should be avoided in young children. Elderly patients are also susceptible to many of the adverse of antihistamines and, in particular, their inappropriate use for postural giddiness should be avoided.

Occasional gastrointestinal adverse effects of antihistamines include nausea, vomiting, diarrhoea, or epigastric pain. Palpitations and arrhythmia have been reported occasionally with most antihistamines. Antihistamines sometimes causes rashes and hypersensitivity reactions (including bronchospasm, angioedema, anaphylaxis) and cross-sensitivity to related drugs may occur. Blood disorders, including agranulocytosis, leucopenia, hemolytic anemia, and thrombocytopenia, although rare, have also been reported. Other reported adverse effects include convulsions, sweating, myalgia, paraesthesias, extrapyramidal effects, tremor, sleep disturbances, depression, confusion, tinnitus, hypotension, and hair loss.

Sedative actions apply to a lesser extent with the non-sedating antihistamines; they do not appear to potentiate the effects of alcohol, but it should be avoided in excess. Antihistamines may suppress the cutaneous histamine response to allergen extracts and should be stopped several days before skin testing.

Store at temperatures not exceeding 30°C. Protect from light.

Antihistamines & Antiallergics

R06AE09 - levocetirizine ; Belongs to the class of piperazine derivatives used as systemic antihistamines.

Rx