Ibuprofen, an NSAID, has analgesic, anti-inflammatory and antipyretic properties. It inhibits cyclooxygenase-1 and 2 thereby, also inhibiting prostaglandin synthesis.
Onset: Analgesic: 30-60 minutes. Anti-inflammatory: ≤7 days (oral).
Duration: 4-6 hours (oral).
Pharmacologic Classification: Non-Steroidal Anti-Inflammatory.
Pharmacology: Pharmacokinetics: Absorption: Absorbed from the gastrointestinal tract, partially into the skin, and almost completely absorbed after rectal administration. Food intake decreases absorption rate. Time to peak plasma concentration: 1-2 hours (oral); 0.75 hours (rectal).
Distribution: Enters breast milk. Plasma protein binding: 90-99%.
Metabolism: Metabolised in the liver via oxidation.
Excretion: Mainly via urine (45-80% as metabolites, approx 1% as unchanged drug); faeces. Elimination half-life: Approx 2 hours.
Relief of fever; mild to moderate aches & pains eg, dental pain including teething pain, toothache, muscular aches or soft tissue injuries including sprains & strains, headache, common cold, flu or sore throat; other types of pain eg, earache, or pain after vaccination or surgery; inflammation from juvenile RA.
Relief of mild to moderate aches & pain eg, headache including migraine, neuralgia, muscular aches including minor arthritis pain, backache (including low back pain), dysmenorrhea; inflammation from arthritis, non-serious arthritic conditions.
The recommended oral dose is 300 mg, 2 to 3 times daily maximum of 1.2 grams or as prescribed by the physician.
Children: 11 years: 3 teaspoonful (15 mL).
9-10 years: 2 teaspoonful ½ teaspoon (12.5 mL).
6-8 years: 2 teaspoonful (10 mL).
4-6 years: 1 teaspoonful ½ teaspoon (7.5 mL).
2-3 years: 1 teaspoon (5 mL).
To be taken 6-8 hourly. Maximum 3 x a day or as prescribed by the physician.
Should be taken with food.
The most frequently reported symptoms of ibuprofen overdose include abdominal pain, nausea, vomiting, fatigue (lethargy) and drowsiness. Other symptoms include headache, ringing in the ears (tinnitus), central nervous system depression, convulsions, low blood pressure, and irregular heartbeat. Excessive acidity of the blood (metabolic acidosis), coma, acute kidney failure, too much potassium in the blood (hyperkalemia), absence of spontaneous breathing (apnea), respiratory depression, and respiratory failure may rarely occur.
Management: Supportive and symptomatic treatment. Induce emesis with syrup of ipecac or perform gastric lavage. Administer activated charcoal to reduce absorption and reabsorption. Forced alkaline diuresis might be beneficial. Management of hypotension, gastrointestinal bleeding and acidosis may also be necessary.
Patients with known hypersensitivity to ibuprofen: unresolved dyshematopoiesis; patients with ulcers in the stomach and duodenum.
Patient with CV disease or risk factors of (e.g. CHF, ischaemic heart disease, CVA, hypertension, hyperlipidaemia, diabetes mellitus), bleeding disorders, SLE, mixed connective tissue disorders, porphyria. Surgery. Hepatic and renal impairment. Elderly, children (especially premature neonates with risk factors for infection and infants with increased bilirubin levels). Pregnancy (1st-2nd trimester) and lactation. Concomitant use of other NSAIDs, antiplatelets, anticoagulants. Not for prolonged usage.
Decreased blood conc w/ aspirin. Increased risk of stomach & intestinal bleeding w/ phenylbutazone, indomethacin, salicylates & other NSAIDs (eg, mefenamic acid, naproxen, diclofenac, ketoprofen); anticoagulants (eg, warfarin, dicumarol) or thrombolytics (eg, streptokinase); corticosteroids (eg, prednisone, prednisolone), SSRIs (eg, citalopram, escitalopram, sertraline). Acute reduction in kidney function & BP response to ACE inhibitors (eg, captopril, enalapril, ramipril, imidapril, fosinopril, lisinopril). May reduce the effect of mifepristone (do not use 8-12 days after mifepristone); diuretics (eg, furosemide & thiazide). Risk of methotrexate & lithium toxicity. Increased plasma concentration of cardiac glycosides (eg, digitalis). May enhance the effect of phenytoin. Increased risk of nephrotoxicity w/ ciclosporin or tacrolimus.
Protect from light. Store at temperatures not exceeding 30°C.
M01AE01 - ibuprofen ; Belongs to the class of propionic acid derivatives of non-steroidal antiinflammatory and antirheumatic products.
Medbufen oral susp 100 mg/5 mL
60 mL x 1's (P60/bottle)
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