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Metronidazole + Miconazole nitrate (METINDAZ) should be used cautiously in patients with alteration of hematopoietic function, with central and peripheral nervous system disorders.
It is recommended to avoid sexual contacts during the treatment. Administration of the suppositories can reduce the efficacy of local contraception (preservatives, vaginal diaphragms) due to interactions of the suppository base with the latex.
As a prophylaxis for reinfection, simultaneous treatment of sexual partner is recommended and in the case of trichomonadal vaginitis - administration of systemic medicinal products, for example, metronidazole orally.
Patients should be advised not to take alcohol during the therapy and for 3 days after the end of the treatment, because of the possibility of a disulfiram-like reaction.
During the treatment, there may be a change in the values of transaminases and glycemia.
Effects on Ability to Drive and Use Machines: Systemic administration of metronidazole may affect driving and using machines. In comparison with systemic use, topical metronidazole is absorbed in vagina in low concentrations.
Metronidazole + Miconazole nitrate (METINDAZ) may cause dizziness, ataxia, fatigue and weakness, therefore may affect driving or operating machinery.
