Progesterone capsules may interfere with the effects of bromocriptine and may raise the plasma concentration of ciclosporin. Progesterone capsules may affect the results of laboratory tests of hepatic and/or endocrine functions. Metabolism of Progesterone capsules is accelerated by rifamycin an antibacterial agent. The metabolism of Progesterone by human liver microsomes was inhibited by ketoconazole (IC <0.1 μM) Ketoconazole is a known inhibitor of cytochrome P450 3A4. These data therefore suggest that ketoconazole may increase the bioavailability of Progesterone. The clinical relevance of the in vitro findings is unknown.
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