Hypersensitivity & allergic reactions. Discontinue treatment if signs of cardiac arrhythmia occurs. Not recommended for treatment of MRSA infections. Ongoing proarrhythmic conditions (especially women & elderly) eg, acute MI or QT prolongation may lead to increased risk for ventricular arrhythmias (including torsade de pointes) & cardiac arrest. Bullous skin reaction eg, Stevens-Johnson syndrome or toxic epidermal necrolysis. Patients w/ CNS disorders or predispose to seizure or lower seizure threshold; history of psychiatric disease. Fulminant hepatitis. Consider antibiotic-associated diarrhea including colitis in patients who develop serious diarrhea during or after treatment. Tendon inflammation & rupture (especially Achilles tendon) sometimes bilateral. Increased risk of tendonitis & rupture in elderly & concurrently w/ corticosteroids. Symptoms of myasthenia can be exacerbated. History of actual G6PD, galactose intolerance, Lapp lactase deficiency, glucose-galactose malabsorption. Pelvic inflammatory disease eg, associated w/ tubo-ovarian or pelvic abscess. Vision disorders. Concomitant use of medications that can reduced K levels. Perform liver function tests/investigation where indications of liver dysfunction occur. Avoid exposure to either UV irradiation or extensive &/or strong light during treatment. May interfere w/
Mycobacterium spp. culture test. Renal impairment. Effects on ability to drive & use machines. Elderly.
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