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Probenecid decreases the renal tubular secretion of amoxicillin but does not affect clavulanic acid excretion. Concurrent use with co-amoxiclav may result in increased and prolonged blood levels of amoxicillin but not of clavulanic acid.
Co-amoxiclav may reduce the efficacy of oral contraceptives and patients should be warned accordingly.
Penicillins such as co-amoxiclav may decrease the removal of methotrexate from the body increasing the risk of toxicity.
Antibiotics such as co-amoxiclav may alter the effect of anticoagulants such as warfarin.
