Adult 500 mg-1 g bid-tid IV infusion over approx 30 min. Nosocomial pneumonia, peritonitis, febrile neutropenia, septicemia 1 g IV every 8 hr. Cystic fibrosis, meningitis 2 g IV every 8 hr. Childn 3 mth-12 yrBacterial meningitis 40 mg/kg IV every 8 hr over approx 30 min depending on the type & severity of infection, known or suspected susceptibility of the pathogen(s) & patient's condition.
History of hypersensitivity to carbapenems, penicillins or other β-lactams. Discontinue use if severe allergic reaction occurs. Patients w/ severe renal or hepatic impairment; history of epilepsy & CNS impairment; preexisting liver disorder. Development of resistance in pseudomonal hospital-acquired lower resp tract infections. Monotherapy w/ critically ill patients w/ known or suspected Pseudomonas aeruginosa lower resp tract infection. Perform regular sensitivity testing during treatment. Pseudomembranous colitis, history of GI complaints particularly colitis. Provide fluids, electrolytes & protein replacement when indicated. Do not use drugs that delay peristalsis eg, opiates & diphenoxylate w/ atropine. Neurological sequelae (following treatment of severe meningitis). May develop +ve or indirect Coombs' test. Avoid use during pregnancy. Lactation. Infants <3 mth. Elderly.
Sign Out
