Nelapine Drug Interactions

The blood pressure-lowering effect of nifedipine may be potentiated upon co-administration of other antihypertensive drugs.
Nifedipine may potentiate the effect of reserpine, methyldopa and cimetidine.
Cimetidine: Due to its inhibition of cytochrome P-450 3A4, cimetidine elevates the plasma concentrations of nifedipine and may potentiate the antihypertensive effect.
Rifampicin: Strongly induces the cytochrome P-450 3A4 system. Upon co-administration with rifampicin, the bioavailability of nifedipine is distinctly reduced and thus, its efficacy weakened. The use of nifedipine in combination with rifampicin is therefore contraindicated.
Grapefruit juice inhibits the cytochrome P-450 3A4 system. Administration of nifedipine together with grapefruit juice thus results in elevated plasma concentrations of nifedipine due to an increase of drug bioavailability. As a consequence, the blood pressure-lowering effect may be increased.
Cisapride: Simultaneous administration of cisapride and nifedipine may lead to increased plasma concentrations of nifedipine.