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Pharmacology: Pharmacodynamics: Carbimazole (Neomerdin) is a pro-drug which undergoes rapid and virtually complete metabolism to the active metabolite, Thiamazole also known as Methimazole. The method of action is believed to be inhibition of the organification of iodide and the coupling of iodothyronine residues which in turn suppress the synthesis of thyroid hormones.
Pharmacokinetics: Carbimazole (Neomerdin) is an anti-thyroid drug that works by blocking the production of thyroid hormone. It is rapidly absorbed from the gastrointestinal tract with peak plasma concentrations occurring about 1 to 2 hours after oral administration. Carbimazole (Neomerdin) is completely metabolized to Methimazole, the metabolite responsible for its anti-thyroid activity. Carbimazole (Neomerdin) crosses the placenta and is found in breast milk. Primary means of excretion is thru the urine. Elimination half-life may be increased in hepatic and renal impairment.
