Concurrent use of barbiturates, carbamazepine, phenytoin, primidone or rifampicin may enhance the metabolism and reduce the effects of systemic prednisolone. Conversely, oral contraceptives or ritonavir may increase plasma concentrations of prednisolone. Use of prednisolone with potassium-depleting diuretics eg. thiazides or furosemide, may cause excessive potassium loss. There is also an increased risk of hypokalemia with concurrent amphotericin B or bronchodilator therapy with xanthines or β2-agonists. There may be an increased incidence of gastrointestinal bleeding and ulceration when prednisolone is given with NSAIDs. Response to anticoagulants may be altered by prednisolone and requirements of antidiabetic drugs and antihypertensives may be increased. Prednisolone may decrease serum concentrations of salicylates and may decrease the effect of anticholinesterases in myasthenia gravis.
Sign Out
