Neurontin

Gabapentin

Monotherapy in the treatment of partial seizures w/ & w/o secondary generalization in adult & childn ≥12 yr. Adjunctive therapy in the treatment of partial seizures w/ & w/o secondary generalization in adult & childn ≥3 yr. Neuropathic pain in adult ≥18 yr.

Epilepsy Adult & childn >12 yr Dose range: 900-3,600 mg daily. Initially 300 mg tid on day 1 or titrate the dose as 300 mg once daily on day 1, increasing to 300 mg bid on day 2, then 300 mg tid on day 3. Thereafter, increase the dose in 3 equally divided doses up to a max of 3,600 mg daily. Max time between tid doses: 12 hr to prevent breakthrough convulsions. Childn 3-12 yr Initially 10-15 mg/kg daily in 3 equally divided doses, & the effective dose reached by upward titration over a period of approx 3 days. Effective dose: Childn ≥5 yr 25-35 mg/kg daily in 3 equally divided doses; 3-<5 yr 40 mg/kg daily in 3 equally divided doses. Max time interval between doses: 12 hr. Neuropathic pain Adult Initially 900 mg daily in 3 equally divided doses, increased if necessary up to a max of 3,600 mg daily. Titrate the dose as 300 mg once daily on day 1, increasing to 300 mg bid on day 2, then 300 mg tid on day 3. Renal impairment Patient w/ neuropathic pain or epilepsy CrCl ≥80 mL/min 900-3,600 mg daily, 50-79 mL/min 600-1,800 mg daily, 30-49 mL/min 300-900 mg daily, 15-29 mL/min 150-600 mg daily (administer 150 mg as 300 mg every other day), <15 mL/min 150-300 mg daily (administer 150 mg as 300 mg every other day). Administer total daily dose as tid regimen. Patient undergoing hemodialysis who has never received gabapentin 300-400 mg loading dose, then 200-300 mg following each 4 hr of hemodialysis.

May be taken with or without food.

Hypersensitivity.

Systemic hypersensitivity reactions eg, DRESS. Early manifestations of hypersensitivity eg, fever or lymphadenopathy may be present even though rash is not evident. Discontinue if patient experience signs or symptoms of anaphylaxis. May precipitate status epilepticus w/ abrupt w/drawal. Not considered effective in the treatment of absence seizures. Associated w/ dizziness & somnolence which could increase the occurrence of accidental injury (fall). History of drug abuse & dependence. Concomitant use w/ opioids & other CNS depressants. May impair ability to drive or operate machinery. Pregnancy & lactation.

Abdominal pain, back pain, headache; constipation, diarrhea, dyspepsia, dry mouth, nausea, vomiting; peripheral edema, increased wt; amnesia, ataxia, confusion, dizziness, somnolence, abnormal thinking, tremor; pharyngitis; rash; amblyopia. Epilepsy: Fatigue, fever, viral infection; vasodilation; dental abnormalities, increased appetite, dry throat; leukopenia, decreased WBC; fracture, myalgia; abnormal coordination, depression, dysarthria, emotional lability, insomnia, nervousness, nystagmus, twitching; coughing, rhinitis; abrasion, acne, pruritus; diplopia; impotence. Neuropathic pain: Accidental injury, asthenia, flu syndrome, infection, pain; flatulence; abnormal gait, hypesthesia, vertigo; dyspnea.

Resp depression, sedation, & death w/ CNS depressants including opioids. Increased mean AUC w/ morphine. Reduced bioavailability w/ antacids containing Al & Mg. False +ve readings w/ Ames N-Multistix SG dipstick test.

Anticonvulsants / Drugs for Neuropathic Pain

N02BF01 - gabapentin ; Belongs to the class of gabapentinoids. Used to relieve pain and other conditions.

Rx