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Metformin should be given in divided doses with meals. Metformin should be started at low dose usually at 500 mg once a day with meals with gradual increase, both to reduce gastrointestinal adverse effects and to permit identification of the minimum dose required for adequate glycemic control.
Dosage increases should be made at increments of 500 mg per day every 2 weeks, up to a total of 2,500 mg (2.5 g) per day, to be taken in three divided doses with meals. Or as prescribed by the physician.
