Search

Nimbex

Nimbex

cisatracurium

Manufacturer:

GlaxoSmithKline

Distributor:

Aspen
Concise Prescribing Info
Contents
Cisatracurium besilate
Indications/Uses
Surgical procedures including cardiac surgery, other procedures & in intensive care. Adjunct to general anaesth or sedation in ICU to relax skeletal muscles & to facilitate tracheal intubation & mechanical ventilation.
Click to view Nimbex detailed prescribing information
Dosage/Direction for Use
IV bolus inj Tracheal intubation Adult 0.15 mg/kg over 5-10 sec. Maintenance: 0.03 mg/kg. Childn 1 mth-12 yr 0.15 mg/kg over 5-10 sec. Maintenance: 0.02 mg/kg. IV infusion Adult & childn 1 mth-12 yr Initially 3 mcg/kg/min to restore 89-99% T1 suppression then 1-2 mcg/kg/min to maintain block in this range. Adult ICU patients Initially 3 mcg/kg/min.
Click to view Nimbex detailed prescribing information
Overdosage
View Nimbex overdosage for action to be taken in the event of an overdose.
Contraindications
Hypersensitivity to cisatracurium, atracurium, or benzenesulfonic acid.
Click to view Nimbex detailed prescribing information
Special Precautions
Hypersensitivity w/ other neuromuscular blocking agents. Myasthenia gravis & other neuromuscular disease. Severe acid-base &/or serum electrolyte abnormalities. Has not been studied in patients w/ history of malignant hyperthermia & in patients w/ burns. Do not administer into the infusion line of a blood transfusion. Pregnancy & lactation.
Click to view Nimbex detailed prescribing information
Adverse Reactions
Bradycardia; hypotension.
Click to view Nimbex detailed prescribing information
Drug Interactions
Increased effect w/ volatile agents eg, enflurane, isoflurane & halothane; ketamine; other non-depolarising neuromuscular blocking agents; antibiotics (including aminoglycosides, polymyxins, spectinomycin, tetracyclines, lincomycin & clindamycin); anti-arrhythmics (including propranolol, Ca channel blockers, lidocaine, procainamide & quinidine); diuretics (including furosemide & possibly thiazides, mannitol & acetazolamide); Mg salts; lithium salts; ganglion blocking drugs (trimetaphan, hexamethonium). Rarely, may aggravate or unmask latent myasthenia gravis or induce myasthenic syndrome w/ antibiotics, β-blockers (propranolol, oxprenolol), anti-arrhythmics (procainamide, quinidine), anti-rheumatics (chloroquine, D-penicillamine), trimetaphan, chlorpromazine, steroids, phenytoin & lithium. May prolong & complex block w/ suxamethonium. Decreased effect w/ phenytoin or carbamazepine. May shorten duration & diminish magnitude of neuromuscular blockade w/ donepezil.
Click to view Nimbex detailed prescribing information
Caution For Usage
For caution against possible variation of physical aspect of medicine... Click to view Nimbex detailed prescribing information
Storage
View Nimbex storage conditions for details to ensure optimal shelf-life.
Description
View Nimbex description for details of the chemical structure and excipients (inactive components).
Action
View Nimbex mechanism of action for pharmacodynamics and pharmacokinetics details.
MIMS Class
Neuromuscular Blocking Agents
ATC Classification
M03AC11 - cisatracurium ; Belongs to the class of other quaternary ammonium-containing agents used as peripherally-acting muscle relaxants.
Presentation/Packing
Form
Nimbex soln for inj 2 mg/mL
Packing/Price
5 mL x 5 × 1's (P2,150/box)
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Already a member? Sign in
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Already a member? Sign in