Norizec Overdosage

Like other sulfonylureas, glimepiride overdosage may manifest as hypoglycemia which may last for 7-12 hours and may recur after an initial recovery. Symptoms may not be present for up to 24 hours after ingestion.
Aggressively treat mild hypoglycemic symptoms with oral glucose and adjust drug dosage and/or meal patterns. Continue close monitoring until the patient is out of danger.
Prevent absorption of glimepiride by inducing vomiting and then drinking water or lemonade with activated charcoal (adsorbent) and sodium sulfate (laxative). Gastric lavage followed by activated charcoal and sodium sulfate is recommended in case of large ingestions of glimepiride.
In case of severe hypoglycemic reactions including coma, seizure or other neurological impairment, immediate hospitalization is required. In patients with diagnosed or suspected hypoglycemic coma, rapid intravenous injection of concentrated (50%) glucose solution followed by a continuous infusion of 10% glucose solution at a rate that will maintain blood glucose level at 100 mg/dL and above should be given. Monitor patients for 24 to 48 hours to prevent recurrence of hypoglycemia.
In case of accidental ingestion of glimepiride in infants and children, treat hypoglycemic symptoms by giving a carefully controlled dose of glucose (to avoid the possibility of producing hyperglycemia) and close monitoring of blood glucose until the patient is out of danger.