Onzet Overdosage

Tablet: Manifestations that have been reported include severe constipation, visual disturbances, hypotension and a vasovagal episode with transient second degree AV block. In case of suspected overdose, symptomatic and supportive therapy should be given as appropriate, as there is no specific antidote for Ondansetron.
Injection: There is no specific antidote for ondansetron overdose. Patients should be managed with appropriate supportive therapy individual intravenous doses as large as 150 mg and total daily intravenous doses as large as 252 mg have been inadvertently administered without significant adverse events. These doses are more than 10 times the recommended daily dose.
In addition to the adverse reactions listed as follows, the following events have been described in the setting of ondansetron overdose: "Sudden blindness" (amaurosis) of 2 to 3 minutes' duration plus severe constipation occurred in one patient that was administered 72 mg of ondansetron intravenously as a single dose. Hypotension (and faintness) occurred in another patient that took 48 mg of ondansetron hydrochloride tablets. Following infusion of 32 mg over only a 4 minute period, a vasovagal episode with transient second degree heart block was observed. In all instances, the events resolved completely.