Adverse effects reported most frequently with Pantoprazole sodium sesquihydrate have been headache, diarrhea and skin rashes: they have sometimes been severe enough to require discontinuation of treatment. Other effects include pruritus, fatigue, constipation, nausea and vomiting, flatulence, abdominal pain, arthralgia and myalgia, urticaria and dry mouth. Pantoprazole sodium sesquihydrate may also increase the risk of gastrointestinal infections because of their acid suppressive effects.