Each ml contains: Paracetamol 10 mg.
Pharmacology: Paracetamol produces analgesia by raising the threshold of the pain center in the brain and by obstructing impulses at the pain mediating chemoreceptors. The drug produces antipyresis by an action on the hypothalamus; heat dissipation is increased as a result of vasodilation and increased peripheral blood flow.
Pharmacokinetics: Distribution of Paracetamol to most body tissues and fluids is both rapid and uniform. Paracetamol is excreted in the urine primarily as the glucoronide and smaller amounts as the sulphate, mercapturate and unchanged in the urine within 24 hours after administration.
Paracetamol, a para-aminophenol derivative, has analgesic and antipyretic properties and weak anti-inflammatory activity. It may be given by intravenous infusion for the short-term treatment of moderate pain, particularly following surgery, and fever. Paracetamol is often the analgesic or antipyretic of choice, especially in the elderly and in patients in whom salicylates or other NSAIDS are contraindicated, such patients include asthmatics, those with a history of peptic ulcer and children.
Paracetamol is given by intravenous infusion lo adults and children over 10 kg in weight as follow: patients weighing over 50 kg, single doses of 1 g every 4 or more hours, to a maximum of 4 g daily; from 33 to 50 kg, single doses of 15 mg/kg every 4 or more hours, to a maximum of 60 mg/kg or 3 g daily (whichever is less); between 10 and 33kg, single dose of 15mg/kg or 2g daily (whichever is less).
The paracetamol solution is administered as a 15-minute intravenous infusion.
Symptoms of overdosage may include nausea, vomiting, abdominal pain, diaphoresis, generalized weakness and lethargy. If an overdosage of Paracetamol is suspected, blood should be withdrawn immediately for Paracetamol plasma assay, without regard to the presence or absence of symptomology.
Treatment: The acute hepatotoxicity and nephrotoxicity of Paracetamol can be overcome by the administration of sulphydryl donors eg. N-acetylcysteine which should be given as soon as possible after congestion. Treatment after 12 hours is not effective. Paracetamol overdosage should be treated with gastric lavage if the, patient is seen within 24 hours of ingestion of the drug.
Paracetamol should be given with care to patients with impaired kidney or liver function. Not to be given to neonates.
Paracetamol has rarely been found to produce any side effects in therapeutic doses and is usually well tolerated by aspirin sensitive patients. Toxicity may result from a single toxic dose of the drug or from chronic ingestion. The following adverse reactions have been reported; skin eruption, haematological toxicity eg. thrombocytopenia and leucopenia, methaemoglobinaemia which can result in cyanosis, and on long-term use, renal damage can result.
Paracetamol may enhance the activity of coumarin anticoagulants, but the effect is not generally of clinical significance.
Store at temperatures not exceeding 30°C.
N02BE01 - paracetamol ; Belongs to the class of anilide preparations. Used to relieve pain and fever.
Para-IV soln for IV infusion 10 mg/mL
100 mL x 1's
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