MonotherapyPatients w/o CHF Start at 15 or 30 mg once daily. Patients w/ NYHA class I or II heart failure Start at 15 mg once daily. Titrate in increments of 15 mg up to max of 45 mg once daily. Combination w/ metformin or sulfonylurea Initially 15 or 30 mg once daily.
View Piozone overdosage for action to be taken in the event of an overdose.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity. Type 1 diabetes, diabetic ketoacidosis, NYHA class III or IV heart failure, serious hepatic impairment (ALT >2.5x ULN) or active liver disease, active bladder cancer. Pregnancy & lactation.
Symptomatic heart failure; excessive, rapid wt gain, dyspnea, edema; history of bladder cancer, renal impairment, abnormal liver tests. Carefully monitor patients for signs & symptoms of CHF & fluid retention after initiation or dose increase. Perform liver function test prior to therapy & eye exam regularly. Consider risk of fracture especially in women & increased possibility of pregnancy (unless using contraceptive methods). Patients <18 yr.
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