Infections caused by susceptible organisms. Resp tract infections (including otitis media), skin & soft-tissue infections, & uncomplicated genital infections. Prophylaxis & as a component of regimens in the treatment of Mycobacterium avium complex (MAC). Prophylaxis of endocarditis in at-risk patients unable to take penicillin. Management of trachoma & typhoid.
Adult 500 mg as single dose daily for 3 days. Initial dose: 500 mg followed by 250 mg daily for 4 days. Uncomplicated genital infections due to Chlamydia trachomatis 1 g as a single dose. Uncomplicated gonorrhea 2 g as a single dose. Prophylaxis of disseminated MAC infections 1.2 g once wkly.
GI disturbances. Headache, somnolence, & taste disturbances. Agranulocytosis, aggravation of muscular weakness in myasthenia gravis patients, & pancreatitis. Prolongation of QT interval & other arrhythmias, sometimes fatal, including torsades de pointes.
Reduced rate of absorption w/ antacids containing Al or Mg salts. Theoretical possibilities of ergotism w/ ergot derivatives. Impaired metabolism of digoxin (in the gut) in some patients. Increased rifabutin toxicity w/ rifabutin.
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