Primary hypercholesterolemia, heterozygous familial hypercholesterolemia, HoFH as combined (mixed) hyperlipidemia in patients who have not responded adequately to diet & other appropriate measures.
Initially 10-20 mg once daily. Patient who requires large reduction in LDL-cholesterol Initially 40 mg daily. May be adjusted at intervals of 4 wk up to a max of 80 mg daily.
View Q-Tor overdosage for action to be taken in the event of an overdose.
Administration
May be taken with or without food: Avoid excessive consumption (>1 L/day) of grapefruit juice.
Contraindications
Hypersensitivity. Active liver disease or unexplained persistent elevations of serum transaminases. Women of childbearing potential not using adequate contraceptive measures. Pregnancy & lactation. Childn.
Alcohol consumption &/or history of liver disease. Rhabdomyolysis; myalgia, myopathy. Concurrent administration of immunosuppressive drugs, including cyclosporine, fibric acid derivatives, nicotinic acid, azole antifungals or erythromycin. Closely monitor patients on combined therapy w/ warfarin. Use appropriate contraceptive measures during treatment in women of childbearing potential.
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