Do not use in patients w/ type 1 DM. Serious hypersensitivity reactions including anaphylaxis & angioedema. Discontinue or consider temporary interruption if ketoacidosis is suspected. Predisposing factors to ketoacidosis including low β-cell function reserve resulting from pancreatic disorders (eg, type 1 diabetes, history of pancreatitis or pancreatic surgery), reduced insulin dose, caloric intake or increase insulin requirements due to infections, illness or surgery & alcohol abuse. Combination w/ medications known to cause hypoglycaemia eg, insulin & insulin secretagogues (eg, sulfonylureas). Discontinue if pancreatitis; necrotizing fasciitis of the perineum (Fournier's gangrene); bullous pemphigoid is suspected. Patients w/ known risk factors for hospitalization for heart failure eg, history of heart failure or moderate to severe renal impairment. Arthralgia. Interference w/ 1,5-anhydroglucitol assay. Evaluate renal function prior to initiation of therapy & periodically thereafter. Not to be used on (eGFR <45 mL/min/1.73 m
2), severe renal impairment (eGFR <30 mL/min/1.73 m
2) or ESRD. Severe hepatic impairment. Do not use during pregnancy or lactation. Adolescents <18 yr & ped patients. Elderly.
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